Anti-Rictor (IHC)

Anti-Rictor (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00429-T 10 µl (5+ slides) -

6 - 10 business days*

131.00€
IHC-00429 100 µl (50+ slides) -

6 - 10 business days*

493.00€
 
Protein function: Subunit of mTORC2, which regulates cell growth and survival in response to... more
Product information "Anti-Rictor (IHC)"
Protein function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. [The UniProt Consortium]
Keywords: Anti-hAVO3, Anti-AVO3 homolog, Anti-Rapamycin-insensitive companion of mTOR
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00429

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Dog, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00429 maps to a region between residue 1650 and the C-terminus (residue 1708) of human Rapamycin-Insensitive Companion of mTOR using the numbering given in TrEMBL entry Q6R327 (GeneID 253260).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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