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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A301-398A-T | 10 µl (2 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A301-398A | 100 µl | - |
2 - 8 business days* |
588.00€
|
Protein function: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the... more
Product information "Anti-RFWD3"
Protein function: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair. [The UniProt Consortium]
Keywords: | Anti-RFWD3, Anti-RNF201, EC=2.3.2.27, Anti-RING finger protein 201, Anti-E3 ubiquitin-protein ligase RFWD3, Anti-RING-type E3 ubiquitin transferase RFWD3, Anti-RING finger and WD repeat domain-containing protein 3 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A301-398A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: pig, orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A301-398A-T maps to a region between residue 724 and774 of human ring finger and WD repeat domain 3 using the numbering given in entry NP_060594.3 (GeneID 55159). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K15691 | Matching products |
UniProt ID : | Q6PCD5 | Matching products |
Gene ID | GeneID 55159 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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