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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
R1031-15A.100 | 100 µg | - | - |
3 - 19 business days* |
699.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
RAGE is a member of the immunoglobulin superfamily of cell surface molecules that bind molecules... more
Product information "Anti-RAGE (Advanced glycosylation End Product-specific Receptor, Receptor For Advanced Glycosylation"
RAGE is a member of the immunoglobulin superfamily of cell surface molecules that bind molecules which have been irreversibly modified by non-enzymatic glycation and oxidation, and are known as advanced glycation end products (AGEs). RAGE is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity. The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune, inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (A beta). Because A beta is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-A beta interaction is thought to result in oxidative stress leading to neuronal degeneration. Applications: Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Receptor for advanced glycosylation end products, Anti-Advanced glycosylation end product-specific receptor |
Supplier: | United States Biological |
Supplier-Nr: | R1031-15A |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 1C1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | AGER (AAH20669, 23-405aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD. |
Format: | Purified |
Database Information
KEGG ID : | K19722 | Matching products |
UniProt ID : | Q15109 | Matching products |
Gene ID | GeneID 177 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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