Anti-PYK2

Anti-PYK2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-226A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-226A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-226A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin... more
Product information "Anti-PYK2"
Protein function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T- cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption, this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC, this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN, this requires both SRC and PTK2/PYK2. [The UniProt Consortium]
Keywords: Anti-CAKB, Anti-FAK2, Anti-CADTK, Anti-PTK2B, Anti-RAFTK, Anti-FADK 2, Anti-CAK-beta, EC=2.7.10.2, Anti-Focal adhesion kinase 2, Anti-Cell adhesion kinase beta, Anti-Proline-rich tyrosine kinase 2, Anti-Protein-tyrosine kinase 2-beta
Supplier: Bethyl Laboratories
Supplier-Nr: A304-226A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Horse, Rabbit, Guinea Pig_10141, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Cetartiodactyla, Wild Yak, Cat, Naked Mole Rat, African Elephant, Crab-eating Macaque, Chinese Tree Shrew)
Immunogen: synthetic peptide. The epitope recognized by A304-226A-T maps to a region between residue 275 to 325 of human Protein Tyrosine Kinase 2 beta using the numbering given in entry NP_775266.1 (GeneID 2185).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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