58 products were found matching "K05871"!

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Defactinib
Defactinib

Item number: Cay17737-1

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 µM. It is less effective against the related kinase PYK2. Defactinib restores...
Keywords: PF-04554878, VS-6063,...
Application: FAK inhibitor
CAS 1073154-85-4
MW: 510.5 D
From 50.00€ *
Review
PF-4618433
PF-4618433

Item number: SYN-1163-M001

Soluble in DMSO. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent...
Keywords: PF4618433
Application: PYK2 inhibitor
CAS 1166393-85-6
MW: 445,5 D
From 250.00€ *
Review
Anti-phospho-Pyk2 (Tyr402)
Anti-phospho-Pyk2 (Tyr402)

Item number: ARG51707.100

Protein function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the...
Keywords: Anti-phospho-FAK2, Anti-phospho-CAKB, Anti-phospho-RAFTK, Anti-phospho-CADTK, Anti-phospho-PTK2B, Anti-phospho-FADK 2,...
Application: ICC, IF, IHC (paraffin), WB
Host: Rabbit
Species reactivity: human, mouse, rat
From 436.00€ *
Review
Anti-Pyk2
Anti-Pyk2

Item number: ARG55580.100

Protein function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the...
Keywords: Anti-CAKB, Anti-FAK2, Anti-PTK2B, Anti-CADTK, Anti-RAFTK, Anti-FADK 2, Anti-CAK-beta, EC=2.7.10.2, Anti-Focal adhesion...
Application: IHC (paraffin), ICC, IF, WB
Host: Rabbit
Species reactivity: human
584.00€ *
Review
Anti-Pyk2
Anti-Pyk2

Item number: ARG55619.100

Protein function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the...
Keywords: Anti-CAKB, Anti-Fak2, Anti-CADTK, Anti-Ptk2b, Anti-RAFTK, Anti-FADK 2, Anti-CAK-beta, EC=2.7.10.2, Anti-Focal adhesion...
Application: WB
Host: Rabbit
Species reactivity: mouse, rat
584.00€ *
Review
Anti-PYK2
Anti-PYK2

Item number: A304-226A

Protein function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the...
Keywords: Anti-CAKB, Anti-FAK2, Anti-CADTK, Anti-PTK2B, Anti-RAFTK, Anti-FADK 2, Anti-CAK-beta, EC=2.7.10.2, Anti-Focal adhesion...
Application: WB, IP
Host: Rabbit
Species reactivity: human
From 164.00€ *
Review
Anti-PYK2
Anti-PYK2

Item number: A304-227A

Protein function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the...
Keywords: Anti-CAKB, Anti-FAK2, Anti-CADTK, Anti-PTK2B, Anti-RAFTK, Anti-FADK 2, Anti-CAK-beta, EC=2.7.10.2, Anti-Focal adhesion...
Application: WB, IP
Host: Rabbit
Species reactivity: human
From 164.00€ *
Review
PYK2, active human recombinant protein
PYK2, active human recombinant protein

Item number: BPS-40480

Active human PYK2 (GenBank Accession No. U33284), full length with N-terminal His tag, MW=120 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Keywords: FAK2, CAKB, RAFTK, PTK2B, CADTK, FADK 2, CAK-beta, EC=2.7.10.2, Focal adhesion kinase 2, Cell adhesion kinase beta,...
Application: Enzyme kinetics, inhibitor screening
MW: 120 kD
525.00€ *
Review
Defactinib
Defactinib

Item number: LKT-D1722.100

FAK inhibitor.
Keywords: VS-6063, PF-04554878
Application: FAK inhibitor
CAS 1073154-85-4
MW: 510.49 D
From 144.00€ *
Review
Anti-phospho-Pyk2/CAKb (Tyr402), clone 14F6
Anti-phospho-Pyk2/CAKb (Tyr402), clone 14F6

Item number: 0081-100

Keywords: Anti-phospho-CAK-beta (pY402)
Application: WB, ELISA
Host: Mouse
Species reactivity: human, mouse, rat
383.00€ *
Review
PF-431396
PF-431396

Item number: Cay17665-10

Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption....
Keywords: N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methane...
Application: FAK / PYK2 inhibitor
CAS 717906-29-1
MW: 506.5 D
From 43.00€ *
Review
Anti-PTK2B
Anti-PTK2B

Item number: E-AB-15011.120

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase...
Keywords: Anti-CAKB, Anti-FAK2, Anti-PTK2B, Anti-RAFTK, Anti-CADTK, Anti-FADK 2, Anti-CAK-beta, EC=2.7.10.2, Anti-Focal adhesion...
Application: WB, IHC, ELISA
Host: Rabbit
Species reactivity: human, mouse, rat
From 71.00€ *
Review
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