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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P3352-90E.200 | 200 µl | - | - |
3 - 19 business days* |
728.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific... more
Product information "Anti-PXF, CT (Peroxisomal Biogenesis Factor 19, Peroxisomal Farnesylated Protein, 33kD Housekeeping"
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific transferases is indispensable for the cellular sorting of many proteins. Peroxisomal farnesylated protein or PXF, which localizes to the outer surface of peroxisomes, is 93% identical in sequence to human HK33, a predicted 299 amino acid protein. The ubiquitous transcription of the HK33 gene indicates its role as a housekeeping gene. At least four variants of HK33 have been identified, two of which are farnesylated in vitro. Evidence suggests that PXF is involved in the process of peroxisomal biogenesis or assembly. Complementation group J (CG-J) from patients with a peroxisome biogenesis disorder (PBD), such as Zellweger syndrome, has been identified. Human PXF expression restored peroxisomal protein import in fibroblasts from a patient with Zellweger syndrome of CG-J. This patient was homozygous for a point mutation in PXF. These results indicate that PXF is the causative gene for CG-J PBD and suggests that the C-terminal part of the PXF protein, including the CAAX homology box, is required for function. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Peroxin-19, Anti-33 kDa housekeeping protein, Anti-Peroxisomal farnesylated protein, Anti-Peroxisomal biogenesis factor 19 |
Supplier: | United States Biological |
Supplier-Nr: | P3352-90E |
Properties
Application: | ELISA, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide selected from the C-terminal region of human PXF (KLH). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K13337 | Matching products |
UniProt ID : | P40855 | Matching products |
Gene ID | GeneID 5824 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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