Anti-PU.1, clone 1835CT291.10.52

Anti-PU.1, clone 1835CT291.10.52
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F54093-0.05ML 50 µl - -

3 - 10 business days*

326.00€
NSJ-F54093-0.2ML 200 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Transcription factor PU.1 binds to the PU-box, a... more
Product information "Anti-PU.1, clone 1835CT291.10.52"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Transcription factor PU.1 binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). [UniProt] Protein function: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R. Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1. May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing. [The UniProt Consortium]
Keywords: Anti-SPI1, Anti-Transcription factor PU.1, Anti-31 kDa-transforming protein, PU.1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F54093

Properties

Application: WB
Antibody Type: Monoclonal
Clone: 1835CT291.10.52
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant human SPI1/PU.1
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-PU.1, clone 1835CT291.10.52"
Write a review
or to review a product.
Viewed