Protein function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation. [The UniProt Consortium]
synthetic peptide. The epitope recognized by A300-844A-T maps to a region between residue 250 and the C-terminus (residue 305) of human Protein Phosphatase 6, Catalytic Subunit using the numbering given in entry NP_002712.1 (GeneID 5537).