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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A302-470A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A302-470A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Functions as a cation channel involved in fluid-flow mechanosensation by the... more
Product information "Anti-Polycystin-2"
Protein function: Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow, forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality. [The UniProt Consortium]
Keywords: | Anti-PC2, Anti-R48321, Anti-Polycystwin, Anti-Polycystin-2, Anti-Polycystic kidney disease 2 protein, Anti-Autosomal dominant polycystic kidney disease type II protein, Anti-Transient receptor potential cation channel subfamily P member 2 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A302-470A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A302-470A-T maps to a region between residue 918 and 968 of human polycystin-2 using the numbering given in entry NP_000288.1 (GeneID 5311). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K04986 | Matching products |
UniProt ID : | Q13563 | Matching products |
Gene ID | GeneID 5311 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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