Anti-PIEZO1 / FAM38A

Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R- Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. {ECO:0000250, UniProtKB:E2JF22, ECO:0000269, PubMed:20016066, ECO:0000269, PubMed:23479567, ECO:0000269, PubMed:23695678, ECO:0000269, PubMed:25119035}. [The UniProt Consortium]