27 products were found matching "K22128"!

Yaddle1 is an agonist of Piezo1 and a derivative of Yoda1 (Cay-21904). It induces calcium influx in a reporter assay using HEK293A cells expressing human Piezo1 (EC50 = 0.4 µM). Yaddle1 (15 µM) induces calcium influx in primary human CD4+ T cells, which express Piezo1, and does not decrease the viability of isolated...

A Piezo1 agonist, induces calcium influx in HEK cells overexpressing mouse Piezo1 (EC50 = 150 nM), selective for Piezo1 over 30 other ion channels and receptors at 5 µM, induces smooth muscle relaxation in isolated and perfused mouse portal veins (EC50 = 1.2 µM), increases cortical area and thickness at 15 and 37%...

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 µM for murine and human Piezo1-transfected HEK293T cells, respectively). It is selective for Piezo1 as it elicits Ca2+ flux in Piezo1- but not Piezo2-transfected HEK293T cells. Yoda1 slows the inactivation phase of murine Piezo1 transient currents and...

A Piezo1 agonist, induces calcium influx in HEK cells overexpressing mouse Piezo1 (EC50 = 280 nM), induces inward currents in a whole-cell patch-clamp assay using HEK cells overexpressing mouse Piezo1 at 10 µM, induces smooth muscle relaxation in isolated and perfused mouse portal veins (EC50s = 1.14 µM)....

Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining...

The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in...

Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining...

Protein function: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...

Protein function: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...

Dooku1 is an antagonist of yoda1-activated Piezo1 ion channels (IC50 = 1.3 µM in HEK293 cells expressing the human receptor). It is selective for Piezo1 activated by yoda1 (Cay-21904) over constituitively active Piezo1, transient receptor potential vanilloid 4 (TRPV4), and transient receptor potential canonical 4...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2427-2661aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: KSVAGVINQP LDVSVTITLG GYQPIFTMSA QQSQLKVMDQ QSFNKFIQAF SRDTGAMQFL ENYEKEDITV AELEGNSNSL WTISPPSKQK MIHELLDPNS SFSVVFSWSI QRNLSLGAKS EIATDKLSFP...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2198-2431aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: RSVVGVVNQP IDVTVTLKLG GYEPLFTMSA QQPSIIPFTA QAYEELSRQF DPQPLAMQFI SQYSPEDIVT AQIEGSSGAL WRISPPSRAQ MKRELYNGTA DITLRFTWNF...