Anti-PHAX

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-916A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-916A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-916A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the... more
Product information "Anti-PHAX"
Protein function: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. [The UniProt Consortium]
Keywords: Anti-PHAX, Anti-RNUXA, Anti-Phosphorylated adapter RNA export protein, Anti-RNA U small nuclear RNA export adapter protein
Supplier: Bethyl Laboratories
Supplier-Nr: A303-916A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Horse, Rabbit, Guinea Pig_10141, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, European Domestic Ferret, African Elephant, Naked Mole Rat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-916A-T maps to a region between residue 344 and 394 of human Phosphorylated Adaptor for RNA Export using the numbering given in entry NP_115553.2 (GeneID 51808).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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