Anti-Periostin

Anti-Periostin antibody is directed against mouse Periostin protein. This antibody was affinity purified from monospecific antiserum by immunoaffinity purification. The immunogenic peptide is present in all known splice variants of periostin and therefore this antibody recognizes all known molecular forms of periostin. The antibody is suitable for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH 6.0)/ 0.1 % Tween-20). Reactivity is expected from the following species based on 100% sequence homology: most mammalian, avian, amphibian and fishes. Protein function: Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. [The UniProt Consortium]