Anti-PDE9A

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA011380.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA011380.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of... more

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Product information "Anti-PDE9A"

Protein function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 95% and to rat: 95%

Keywords:	Anti-High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA011380

Properties

Application:	ICC, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: ECNIFSNIPP DGFKQIRQGM ITLILATDMA RHAEIMDSFK EKMENFDYSN EEHMTLLKMI LIKCCDISNE VRPMEVAEPW VDCLLEEYFM QSDREKSEGL PVAPFMDRDK VTKATAQIGF IKFVLIPMF (ATA-APrEST70486)