- Search results for K13761
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22 products were found matching "K13761"!
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Item number: Cay24299-25
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. It is over 1,000-fold more selective for PDE9A over 79 non-PDE targets, with the exception of the melatonin MT3/ML2...
Keywords: | 1,5-dihydro-6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyr... |
Application: | PDE9A inhibitor |
CAS | 1082744-20-4 |
MW: | 395.5 D |
From 48.00€
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Item number: ARG10812.50
Protein function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755,...
Keywords: | Anti-High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Application: | IF, ELISA, ICC, IF, IHC, IP, WB, DB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
576.00€
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Item number: BPS-60090
Active human PDE9A2 (GenBank Accession No. NM_001001567), full length with Nterminal GST tag, MW=87.7 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Keywords: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, |
Application: | Enzyme kinetics, inhibitor screening |
MW: | 87.7 kD |
672.00€
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Item number: BPS-60381
Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE9A is primarily expressed in spleen, small intestine, and brain. PDE9 inhibitors have been studied as therapeutics for treatment of cardiovascular diseases, diabetes, and neurodegenerative disorders. The PDE9A Assay...
Keywords: | inhibitor screening, assay kit, PDE9A, |
Application: | Enzyme kinetics, inhibitor screening, HTS |
Species reactivity: | human |
599.00€
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Item number: Cay30375-1
BI-409306 is a potent and selective phosphodiesterase 9A (PDE9A) inhibitor with IC50 values of 65 and 168 nM for the human and rat enzymes, respectively. It is selective for PDE9A over PDE2A, -3A, -4B, -5A, -6AB, -7A and -10A and 95 non-PDE targets at 10 µM but does inhibit human PDE1A and PDE1C (IC50s = 1.45 and...
Keywords: | 1,5-dihydro-6-(2-pyridinylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one |
Application: | Potent, selective PDE9A inhibitor |
CAS | 1189767-28-9 |
MW: | 311.3 D |
From 84.00€
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Item number: Cay32039-100
Phosphodiesterase 9A (PDE9A) is a high-affinity cGMP-specific cyclic nucleotide phosphodiesterase. Alternative splicing in the 5' region of PDE9A mRNA results in a variety of PDE9A isoforms, including PDE9A2, whereas the 3' region encoding the catalytic PDE domain does not vary between isoforms. PDE9A2 mRNA is...
Keywords: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Expressed in: | Insect cells |
Origin: | human |
MW: | 89.5 kD |
513.00€
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Item number: Cay30946-1
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50 = 22 nM). It is selective for PDE9A over PDE1C (IC50 = >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 µM but does inhibit the human...
Keywords: | 1,5-dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one |
Application: | PDE9A inhibitor |
CAS | 1236858-52-8 |
MW: | 395.5 D |
From 66.00€
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Item number: G-PACO57080.50
PDE9A Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, WB, IHC, IF applications. PDE9A Antibody is a high quality polyclonal antibody for research use only.. Protein function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many...
Keywords: | Anti-High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Application: | ELISA, WB, IHC, IF |
Host: | Rabbit |
Species reactivity: | human |
363.00€
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Item number: ATA-HPA011380.100
Protein function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755,...
Keywords: | Anti-High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Application: | ICC, IHC |
Host: | Rabbit |
Species reactivity: | human |
From 335.00€
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Item number: ELK-ELK9635.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDE9A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDE9A. Next,...
Keywords: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: VHPS-6740
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Keywords: | PDE9A, EC=3.1.4.35, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Application: | RNA quantification |
43.00€
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Item number: VMPS-4634
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Keywords: | Pde9a, Pde8b, EC=3.1.4.35, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Application: | RNA quantification |
43.00€
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