Anti-PARP

Anti-PARP
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG65772.50 50 µg - -

6 - 14 business days*

436.00€
ARG65772.100 100 µg - -

6 - 14 business days*

624.00€
 
Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the... more
Product information "Anti-PARP"
Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of histones in a C4orf27/HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy- consuming (PubMed:27257257). [The UniProt Consortium]
Keywords: Anti-PARP1, Anti-ADPRT, Anti-ARTD1, Anti-PARP-1, Anti-ADPRT 1, EC=2.4.2.30, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose] polymerase 1, Anti-NAD(+) ADP-ribosyltransferase 1, Anti-ADP-ribosyltransferase diphtheria toxin-like 1
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG65772

Properties

Application: WB
Antibody Type: Monoclonal
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Synthetic peptide from Human PARP
MW: 113 kD
Format: Antigen Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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