Anti-Paraoxonase 1 (Paraoxonase-1, PON1, Aromatic Esterase 1, A-esterase 1, Esterase-A, ESA, K-45, P

In humans, the paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3. PON1 is synthesized primarily in the liver, and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). PON1 hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:2000 (titer)., Western Blot: 1-3ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human Liver lysates, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.