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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay25965-100 | 100 µg | - |
6 - 10 business days* |
535.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein arginine deiminase 6 (PAD6) is a homodimeric guanidine-modifying enzyme belonging to the... more
Product information "Anti-PAD6 (Clone 4B7)"
Protein arginine deiminase 6 (PAD6) is a homodimeric guanidine-modifying enzyme belonging to the amidinotransferase superfamily. It is a calcium-dependent enzyme that catalyzes the post-translational modification of target proteins by converting arginine to citrulline. PAD6 is expressed in mammalian oocytes, sperm cells, and early embryos. In mammalian oocytes and early embryo cytoplasm, its expression is localized to cytoskeletal sheets, dynamic structures containing various keratins, which are major targets for citrullination. PAD6-/- oocytes exhibit reduced microtubule acetylation and defective organelle positioning and redistribution, suggesting a role for PAD6 in regulating microtubule-mediated organelle movement and positioning. PAD6-/- female, but not male, mice are infertile due to a reduction of de novo protein synthesis, cytoskeletal sheet formation, and ribosomal RNA which induces arrest of zygote development at the two-cell stage. PAD6 is regulated by newborn ovary homeobox (Nobox), as its promoter contains a Nobox DNA-binding element (NBE) and expression and activity of PAD6 are decreased in Nobox-/- mouse ovaries. In human females, homozygous nonsense mutations and compound-heterozygous mutations in PAD6 induce early embryonic arrest following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Cayman's PAD6 monoclonal antibody (Clone 4B7) can be used for Western blot and ELISA applications. The antibody recognizes PAD6 at ~77 kDa from human samples.Synonyms: PADI6, hPADVI, Peptidylarginine Deiminase 6, Protein Arginine Deiminase 6. Immunogen: Full-length human recombinant PAD6 protein. Clone Designation: 4B7. MW: ~77 kDa. Formulation: (Request formulation change), 100 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA and WB. Cross Reactivity: (-) PAD1, (-) PAD2, (-) PAD3, (-) PAD4. UniProt Accession #: Q6TGC4.
Keywords: | Anti-PAD6, Anti-PADI6, Anti-hPADVI, Anti-hPADVI, Anti-Peptidylarginine deiminase VI, Anti-Peptidylarginine deiminase VI, Anti-Protein-arginine deiminase type-6, Anti-Protein-arginine deiminase type-6, Anti-Protein-arginine deiminase type VI, Anti-Protein- |
Supplier: | Cayman Chemical |
Supplier-Nr: | 25965 |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 4B7 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Full-length human recombinant PAD6 protein |
Format: | Purified |
Database Information
KEGG ID : | K01481 | Matching products |
UniProt ID : | Q6TGC4 | Matching products |
Gene ID | GeneID 353238 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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