119 products were found matching "K01481"!
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Cl-Amidine (hydrochloride)
Item number: Cay10599-1
Cl-Amidine is an irreversible inhibitor of protein arginine deiminases (PADs, IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively). It is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 µM, respectively). Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil...
| Keywords: | N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide, monohydrochloride |
| Application: | Peptidyl arginine deiminase (PAD) inhibitor |
| CAS | 1373232-26-8 |
| MW: | 347.2 D |
From 67.00€
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Protein-arginine deiminase type-1 (PADI1), recombinant human
Item number: CSB-EP891543HUc7.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-663aa. Protein Length: Full Length. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ EDQALGRSVL YLTGVDISLE VDTGRTGKVK...
| Keywords: | PAD1, PADI1, Peptidylarginine deiminase I, Protein-arginine deiminase type I, Protein-arginine deiminase type-1 |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 81.6 kD |
From 219.00€
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Anti-PADI2
Item number: ABS-KC-1205.100
Protein function: Catalyzes the deimination of arginine residues of proteins. [The UniProt Consortium]
| Keywords: | Anti-Protein-arginine deiminase type-2, Anti-PAD-H19, Anti-Peptidylarginine deiminase II, Anti-Protein-arginine deiminase... |
| Host: | Mouse |
| Species reactivity: | human |
From 232.00€
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Anti-PADI2
Item number: ABS-KC-1206.100
Protein function: Catalyzes the deimination of arginine residues of proteins. [The UniProt Consortium]
| Keywords: | Anti-Protein-arginine deiminase type-2, Anti-PAD-H19, Anti-Peptidylarginine deiminase II, Anti-Protein-arginine deiminase... |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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Anti-PADI2
Item number: ABS-KC-1207.100
Protein function: Catalyzes the deimination of arginine residues of proteins. [The UniProt Consortium]
| Keywords: | Anti-Protein-arginine deiminase type-2, Anti-PAD-H19, Anti-Peptidylarginine deiminase II, Anti-Protein-arginine deiminase... |
| Host: | Mouse |
| Species reactivity: | human |
From 232.00€
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GSK484 (hydrochloride)
Item number: Cay17488-5
GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human...
| Keywords: | [(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]... |
| Application: | Reversible PAD4 inhibitor |
| CAS | 1652591-81-5 |
| MW: | 510 D |
From 52.00€
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GSK 199 (hydrochloride)
Item number: Cay17489-5
GSK 199 is an inhibitor of peptidyl arginine deiminase 4 (PAD4, IC50 = 200 nM in the absence of calcium). It selectively inhibits the production of citrulline by PAD4 over PAD1, PAD2, and PAD3 in kinetic assays. GSK 199 (10 µM) prevents histone H3 citrullination and neutrophil extracellular trap (NET) formation...
| Keywords: | [(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone,... |
| Application: | Reversible PADI4 inhibitor |
| CAS | 1549811-53-1 |
| MW: | 469 D |
From 108.00€
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GSK484 hydrochloride
Item number: TGM-TQ0067-100mg
Description: GSK484 hydrochloride (GTPL8577) is a specifc and reversible peptidyl arginine deiminase 4 (PAD4) inhibitor. It demonstrates high-affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. Target: PAD. Smiles: Cl.COc1cc(cc2nc(-c3cc4ccccc4n3CC3CC3)n(C)c12)C(=O)N1CC[C@@H](O)[C@@H](N)C1....
| Keywords: | AOB6992, GTPL8577 |
| Application: | Reversible PAD4 inhibitor |
| CAS | 1652591-81-5 |
| MW: | 510.03 D |
From 67.00€
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PAD2 (human, recombinant)
Item number: Cay10785-50
Peptidyl arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is composed of an alpha/beta propeller domain, an IgG1 domain that contains calcium...
| Keywords: | PADI2, PAD-H19, PAD-H19, KIAA0994, Peptidylarginine deiminase II, Peptidylarginine deiminase II, Protein-arginine... |
| Application: | Enzyme activity |
657.00€
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YW3-56 (hydrochloride) (technical grade)
Item number: TGM-T36108-100mg
Description: YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 µM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 µM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in...
| Keywords: | YW3-56 (hydrochloride) (technical grade) |
| Application: | PADI2 / PADI4 inhibitor |
| CAS | 2309756-20-3 |
| MW: | 530.49 D |
From 2,421.00€
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CAY10727
Item number: TGM-T36393-1mg
Description: CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3, kinact/KI= 15,600 M-1min-1).1It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively). Target: Others. Smiles: ClC1=C(C2=CC(CN3C(=O)C(CCCNC(CCl)=N)NC3=O)=CC=C2)C=CC=C1. References: Jamali,...
| Application: | PADI3 inhibitor |
| CAS | 1671088-84-8 |
| MW: | 433.33 D |
From 295.00€
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Citrulline-specific Probe-Rhodamine
Item number: TGM-T36104-1mg
Description: Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a...
| Application: | Fluorescent citrullination detection |
| CAS | 2309313-01-5 |
| MW: | 731.75 D |
From 443.00€
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