Anti-p53, clone BP53.12

Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-301-174 100 µg - -

3 - 9 business days*

Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or... more
Product information "Anti-p53, clone BP53.12"
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Induces the transcription of long intergenic non- coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53- inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor antigen p53
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-301-174


Application: ELISA, ChIP, IHC, IFM, IP, WB
Antibody Type: Monoclonal
Clone: BP53.12
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: recombinant human p53

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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