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Pifithrin-alpha
Pifithrin-alpha

Item number: Cay13326-5

Pifithrin-alpha is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 µM and in human umbilical vein endothelial cells at 30 µM. Pifithrin-alpha can also protect cells from DNA damage-induced...
Keywords: PFT-alpha, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide
Application: P53 inactivator
CAS 63208-82-2
MW: 367.3 D
From 64.00€ *
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CBL0137
CBL0137

Item number: Cay19110-1

CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-kappaB with an EC50 of 0.47 µM. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-kappaB and promoting cancer cell death. CBL0137 has broad...
Keywords: CBLC137, Curaxin 137, 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone
Application: Curaxin, P53 activator, NF-kappaB inhibitor
CAS 1197996-80-7
MW: 336.4 D
From 110.00€ *
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PRIMA-1MET
PRIMA-1MET

Item number: Cay9000487-5

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Cay-63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1MET is a methylated derivative of PRIMA-1 that...
Keywords: APR 246, 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Application: Mutant p53 apoptotic function re-activator
CAS 5291-32-7
MW: 199.3 D
From 69.00€ *
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Anti-p53
Anti-p53

Item number: A300-247A

Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: WB, IP, IHC, ChIP-Seq, FC
Reactivity: Human
From 125.00€ *
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Anti-p53
Anti-p53

Item number: A300-249A-T

Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: WB, IP, IHC
Reactivity: Human
From 125.00€ *
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Cyclic Pifithrin-alpha (hydrobromide)
Cyclic Pifithrin-alpha (hydrobromide)

Item number: Cay14748-10

Pifithrin-alpha (PFT-alpha, Cay-13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-alpha, also known as PFT-beta, is a stable analog of PFT-alpha, formed by the condensation of pifithrin-alpha in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and...
Keywords: Cyclic PFT-alpha, PFT-beta, Pifithrin-beta, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole,...
Application: PFT-alpha analog, P53-dependent transcription / apoptosis inhibitor
CAS 511296-88-1
MW: 349.3 D
From 57.00€ *
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Anti-p53 / TP53, clone PAb240
Anti-p53 / TP53, clone PAb240

Item number: NSJ-V8130-100UG

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The specificity of this monoclonal antibody to its intended target was tested by HuProtTM Array, containing more than 19,000, full-length human proteins. PAb240 binds to the C-terminus (aa213-217) of both wild type and mutated p53. Mutation and/or...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: ELISA
Reactivity: Human
From 251.00€ *
Review
Anti-p53 / TP53, clone PAb240
Anti-p53 / TP53, clone PAb240

Item number: NSJ-V8130SAF-100UG

1 mg/ml in 1X PBS, BSA free, sodium azide free. The specificity of this monoclonal antibody to its intended target was tested by HuProtTM Array, containing more than 19,000, full-length human proteins. PAb240 binds to the C-terminus (aa213-217) of both wild type and mutated p53. Mutation and/or allelic loss of p53...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: ELISA
Reactivity: Human
541.00€ *
Review
Anti-p53 / TP53, clone DO-1
Anti-p53 / TP53, clone DO-1

Item number: NSJ-V8132-100UG

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 20-25) of p53. Monoclonal antibody PAb1801 does not block the binding of...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: FC, IF, WB, IHC (paraffin)
Reactivity: Human
From 251.00€ *
Review
Anti-p53 / TP53, clone DO-1
Anti-p53 / TP53, clone DO-1

Item number: NSJ-V8132SAF-100UG

1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 20-25) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: FC, IF, WB, IHC (paraffin)
Reactivity: Human
541.00€ *
Review
Anti-p53 / TP53, clone SPM589
Anti-p53 / TP53, clone SPM589

Item number: NSJ-V9089IHC-7ML

Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. Protein function: Acts as a tumor suppressor in many tumor types, induces...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: IHC (paraffin)
Reactivity: Human
541.00€ *
Review
Anti-p53 / TP53, clone SPM590
Anti-p53 / TP53, clone SPM590

Item number: NSJ-V9090IHC-7ML

Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is...
Keywords: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor...
Application: IHC (paraffin)
Reactivity: Human
541.00€ *
Review
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