703 products were found matching "K04451"!

A stabilizer of mutant p53, increases the thermal stability and inhibits aggregation of the mutant p53Y220C DNA-binding domain (Kd = 4 µM), selectively inhibits growth of NUGC-3 cells expressing p53Y220C over WI38 cells that do not express the p53Y220C mutant (IC50s = 90 and >120 µM, respectively), selectively...

Description: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process....

0.5mg/ml if reconstituted with 0.2ml sterile DI water. p53, also known as Tumor Protein 53, is a crucial tumor suppressor protein that plays an essential role in maintaining cellular integrity by regulating the cell cycle, promoting DNA repair, and initiating apoptosis in response to stress, including DNA damage,...

TP53(tumor protein p53) Homo sapiens This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis,...

Rezatapopt is a reactivator of p53 containing a tyrosine-to-cysteine substitution at position 220 (p53Y220C). It increases p53Y220C DNA binding by 1.5-fold in a time-resolved FRET (TR-FRET) assay when used at a concentration of 9 nM. Rezatapopt decreases the proliferation of NUGC-3 gastric carcinoma cells (IC50 =...

Pifithrin-alpha is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 µM and in human umbilical vein endothelial cells at 30 µM. Pifithrin-alpha can also protect cells from DNA damage-induced...

CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-kappaB with an EC50 of 0.47 µM. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-kappaB and promoting cancer cell death. CBL0137 has broad...

Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this...

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Cay-63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1MET is a methylated derivative of PRIMA-1 that...

Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this...

The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman's p53 Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA...

Pifithrin-alpha (PFT-alpha, Cay-13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-alpha, also known as PFT-beta, is a stable analog of PFT-alpha, formed by the condensation of pifithrin-alpha in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and...