Anti-P2RX1 / P2X purinoceptor 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. P2RX1 antibody detects P2X purinoceptor 1, encoded by the P2RX1 gene on chromosome 17p13.2. P2RX1 antibody is widely used in neurobiology, immunology, and cardiovascular research. P2X1 is a ligand-gated ion channel activated by extracellular ATP, mediating rapid influx of cations including sodium, potassium, and calcium. It plays essential roles in neurotransmission, platelet activation, and smooth muscle contraction.Structurally, P2X1 is a ~45 kDa trimeric protein with two transmembrane domains, a large extracellular ligand-binding loop, and intracellular N- and C-terminal regions. ATP binding induces conformational changes that open the channel pore. P2X1 is expressed in platelets, neurons, smooth muscle, and immune cells, reflecting its diverse functions.Functionally, P2X1 mediates fast excitatory responses in neurons, regulates platelet aggregation, and contributes to vasoconstriction in vascular smooth muscle. It also influences immune cell activation and inflammation. Researchers use P2RX1 antibody to study purinergic signaling, hemostasis, and neuroimmune interactions.Clinically, P2RX1 has been implicated in thrombosis, hypertension, and fertility. Knockout studies in mice demonstrate roles in male fertility due to defective vas deferens contraction. P2X1 antagonists are under investigation as antithrombotic agents. NSJ Bioreagents provides P2RX1 antibody for research in purinergic signaling, cardiovascular biology, and platelet physiology.Experimentally, P2RX1 antibody is applied in western blotting to detect the ~45 kDa channel, in immunofluorescence to study membrane localization, and in immunohistochemistry to assess tissue distribution. Functional studies with P2RX1 antibody support analysis of ATP-gated ion channel activity.