Anti-Olig2

Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor that is essential to the formation of oligodendrocytes and motor neurons in the spinal cord and somatic motor neurons in the hindbrain. It represses differentiation and sustains the replication competent state of uncommitted progenitor cells to expand the progenitor cell pool during early development and promotes the cell fate decision to form oligodendrocyte progenitors and motor neurons in the spinal cord during late development. It also suppresses the formation of astrocytes in the spinal cord. Olig2 overexpression enhances oligodendrocyte regeneration and myelin repair in a mouse model of lysophosphatidylcholine-induced demyelination. Knockdown of Olig2 in neurospheres prevents glioma formation but not neurosphere engraftment in mice. Cayman's Olig2 Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes Olig1 at approximately 32 kDa from human, mouse, and rat samples.Synonyms: Class B Basic Helix-Loop-Helix Protein 1, Class E Basic Helix-Loop-Helix Protein 19, Oligodendrocyte Lineage Transcription Factor 2, Oligodendrocyte-specific BHLH Transcription Factor 2, Oligo2. Immunogen: Recombinant mouse Olig2. MW: ~32 kDa. Formulation: (Request formulation change), 100 µl of protein A-purified polyclonal antibody. Storage Buffer: 200 mM Tris, pH 8.0, with 100 mM glycine. Host: Rabbit. Applications: ICC, IHC, IP, WB.