Anti-NUMBL

Anti-NUMBL
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-719A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A301-719A 100 µl (100 µg) -

3 - 9 business days

443.00€
 
Protein function: Plays a role in the process of neurogenesis. Required throughout embryonic... more
Product information "Anti-NUMBL"
Protein function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [The UniProt Consortium]
Keywords: Anti-NUMBL, Anti-Numb-R, Anti-Numb-like protein, Anti-Numb-related protein
Supplier: Bethyl Laboratories
Supplier-Nr: A301-719A-T

Properties

Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by A301-719A-T maps to a region between residue 545 and 595 of human numb (Drosophila) homolog-like using the numbering given in entry NP_004747.1 (GeneID 9253).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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