Anti-Notch 2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG58767.100	100 µl		-	-	6 - 14 business days*		707.00€

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Protein function: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2... more

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Product information "Anti-Notch 2"

Protein function: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL- induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). [The UniProt Consortium]

Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG58767

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Recombinant fusion protein corresponding to aa. 2242-2471 of Human Notch2 (NP_077719.2)
MW:	265 kD
Format:	Affinity Purified