Anti-Notch 1 (Notch1, Notch-1, Neurogenic Locus Notch Homolog Protein 1, hN1, TAN1, Translocation-as

Anti-Notch 1 (Notch1, Notch-1, Neurogenic Locus Notch Homolog Protein 1, hN1, TAN1, Translocation-as
Item number Size Datasheet Manual SDS Delivery time Quantity Price
N5375-08C.20 20 µl - -

3 - 19 business days*

462.00€
N5375-08C.100 100 µl - -

3 - 19 business days*

834.00€
 
Notch1 is a transmembrane protein functioning in development and the determination of cell fate... more
Product information "Anti-Notch 1 (Notch1, Notch-1, Neurogenic Locus Notch Homolog Protein 1, hN1, TAN1, Translocation-as"
Notch1 is a transmembrane protein functioning in development and the determination of cell fate (1). During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain (2). Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1743 and Val1744 (3,4). The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription. Applications: Suitable for use in Immunofluorescence, Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence (IF-IC): 1:200, Flow Cytometry: 1:800, Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-NICD, Anti-Notch 1 intracellular domain, Anti-Notch 1 extracellular truncation, Anti-Neurogenic locus notch homolog protein 1, Anti-Translocation-associated notch protein TAN-1
Supplier: United States Biological
Supplier-Nr: N5375-08C

Properties

Application: FC, IF, WB
Antibody Type: Monoclonal
Clone: 11C1054(D6F11)
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Synthetic peptide corresponding to residues surrounding Gln2497 of human notch1.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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