- Search results for K02599
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90 products were found matching "K02599"!
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Item number: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
Keywords: | gamma-Secretase Inhibitor XXI,... |
Application: | gamma-Secretase inhibitor |
CAS | 209986-17-4 |
MW: | 490.5 D |
From 254.00€
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-10 %
Discount Promotion
Item number: ELK-ELK0436.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TAN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TAN1. Next,...
Keywords: | Notch1 |
Application: | ELISA |
Species reactivity: | rat |
352.00€
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From 316.80€
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Item number: BPS-78747
Notch1dE Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce most mammalian cells, including primary and non-dividing cells. These lentiviruses express a truncated human Notch1 construct (Notch1dE) in which the entire extracellular domain was...
Keywords: | TAN1, NOTCH1, |
Application: | Notch signaling pathway activity monitoring |
Species reactivity: | human |
1,295.00€
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Item number: Cay37432-100
IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Cay-27920). It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and...
Keywords: | 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl],phenoxy]-acetic acid |
Application: | Notch ternary complex formation inhibitor |
CAS | 331862-41-0 |
MW: | 325.4 D |
From 82.00€
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Item number: BPS-60509
Notch Pathway Reporter kit is designed for monitoring the activity of Notch signaling pathway in the cultured cells. The kit contains the transfection-ready Notch1 NICD expression vector and CSL (CBF1/RBP-Jkappa) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains a...
Keywords: | Notch reporter, PKA reporter, cAMP reporter, luciferase reporter , CSL reporter, CBF1 reporter, RBP-J reporter, |
Application: | Notch activity assays |
869.00€
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Item number: A301-895A
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
Keywords: | Anti-TAN1, Anti-NOTCH1 |
Application: | WB, IP, IHC |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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-10 %
Item number: AG-CR1-0081-M005
Cell permeable, potent, selective, non-transition state and non-competitive and gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.
Keywords: | (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide |
Application: | gamma-secretase inhibitor |
CAS | 209986-17-4 |
MW: | 490,5 D |
88.00€
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From 79.20€
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Item number: 100-401-407
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
Keywords: | Anti-TAN1, Anti-NOTCH1 |
Application: | ELISA, IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
684.00€
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Item number: BPS-79503
Notch Pathway Reporter kit is designed for monitoring the activity of the Notch signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for Human NOTCH1 that has a deletion of the entire extracellular domain, leaving the transmembrane and intracellular domains intact (Notch1DE)....
Keywords: | Notch reporter, PKA reporter, cAMP reporter, luciferase reporter , CSL reporter, CBF1 reporter, RBP-J reporter, Cell based... |
Application: | Notch signaling pathway activity monitoring, activator / inhibitor screening |
Species reactivity: | human |
956.00€
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Item number: IHC-00538
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
Keywords: | Anti-TAN1, Anti-NOTCH1 |
Application: | IHC |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: Cay27919-1
Crenigacestat is an orally bioavailable Notch inhibitor. It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells. Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.Formal Name:...
Keywords: | LY3039478,... |
Application: | Notch inhibitor, Antineoplastic |
CAS | 1421438-81-4 |
MW: | 464.4 D |
From 60.00€
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Item number: BPS-60652
The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the...
Keywords: | Notch, NICD, PKA, cAMP, luciferase reporter, |
Application: | Notch signaling assays, inhibitor screening |
Host: | HEK293 |
Species reactivity: | human |
3,104.00€
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