90 products were found matching "K02599"!

1 from 8 pages
No results were found for the filter!
Compound E
Compound E

Item number: Cay15579-1

gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
Keywords: gamma-Secretase Inhibitor XXI,...
Application: gamma-Secretase inhibitor
CAS 209986-17-4
MW: 490.5 D
From 254.00€ *
Review
-10 %
Discount Promotion
Rat TAN1 (Translocation Associated Notch Homolog 1) ELISA Kit
Rat TAN1 (Translocation Associated Notch Homolog 1) ELISA...

Item number: ELK-ELK0436.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TAN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TAN1. Next,...
Keywords: Notch1
Application: ELISA
Species reactivity: rat
352.00€ * From 316.80€ *
Review
Notch1dE Lentivirus
Notch1dE Lentivirus

Item number: BPS-78747

Notch1dE Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce most mammalian cells, including primary and non-dividing cells. These lentiviruses express a truncated human Notch1 construct (Notch1dE) in which the entire extracellular domain was...
Keywords: TAN1, NOTCH1,
Application: Notch signaling pathway activity monitoring
Species reactivity: human
1,295.00€ *
Review
IMR-1A
IMR-1A

Item number: Cay37432-100

IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Cay-27920). It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and...
Keywords: 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl],phenoxy]-acetic acid
Application: Notch ternary complex formation inhibitor
CAS 331862-41-0
MW: 325.4 D
From 82.00€ *
Review
Notch Reporter Assay Kit (cAMP/PKA pathway)
Notch Reporter Assay Kit (cAMP/PKA pathway)

Item number: BPS-60509

Notch Pathway Reporter kit is designed for monitoring the activity of Notch signaling pathway in the cultured cells. The kit contains the transfection-ready Notch1 NICD expression vector and CSL (CBF1/RBP-Jkappa) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains a...
Keywords: Notch reporter, PKA reporter, cAMP reporter, luciferase reporter , CSL reporter, CBF1 reporter, RBP-J reporter,
Application: Notch activity assays
869.00€ *
Review
Anti-Notch1
Anti-Notch1

Item number: A301-895A

Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
Keywords: Anti-TAN1, Anti-NOTCH1
Application: WB, IP, IHC
Host: Rabbit
Species reactivity: human
From 164.00€ *
Review
-10 %
Compound E
Compound E

Item number: AG-CR1-0081-M005

Cell permeable, potent, selective, non-transition state and non-competitive and gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.
Keywords: (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
Application: gamma-secretase inhibitor
CAS 209986-17-4
MW: 490,5 D
88.00€ * From 79.20€ *
Review
Anti-Notch1, cleaved, NT
Anti-Notch1, cleaved, NT

Item number: 100-401-407

Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
Keywords: Anti-TAN1, Anti-NOTCH1
Application: ELISA, IHC, WB
Host: Rabbit
Species reactivity: human
684.00€ *
Review
Notch1 Pathway Reporter Kit (Human)
Notch1 Pathway Reporter Kit (Human)

Item number: BPS-79503

Notch Pathway Reporter kit is designed for monitoring the activity of the Notch signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for Human NOTCH1 that has a deletion of the entire extracellular domain, leaving the transmembrane and intracellular domains intact (Notch1DE)....
Keywords: Notch reporter, PKA reporter, cAMP reporter, luciferase reporter , CSL reporter, CBF1 reporter, RBP-J reporter, Cell based...
Application: Notch signaling pathway activity monitoring, activator / inhibitor screening
Species reactivity: human
956.00€ *
Review
Anti-Notch1 (IHC)
Anti-Notch1 (IHC)

Item number: IHC-00538

Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
Keywords: Anti-TAN1, Anti-NOTCH1
Application: IHC
Host: Rabbit
Species reactivity: human
From 164.00€ *
Review
Crenigacestat
Crenigacestat

Item number: Cay27919-1

Crenigacestat is an orally bioavailable Notch inhibitor. It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells. Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.Formal Name:...
Keywords: LY3039478,...
Application: Notch inhibitor, Antineoplastic
CAS 1421438-81-4
MW: 464.4 D
From 60.00€ *
Review
Notch reporter cell line, 1.5x10(6) cells
Notch reporter cell line, 1.5x10(6) cells

Item number: BPS-60652

The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the...
Keywords: Notch, NICD, PKA, cAMP, luciferase reporter,
Application: Notch signaling assays, inhibitor screening
Host: HEK293
Species reactivity: human
3,104.00€ *
Review
1 from 8 pages