Anti-NKX2.1 / TTF-1, clone HBNK2-2R

Anti-NKX2.1 / TTF-1, clone HBNK2-2R
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3732SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. NKX2.1/TTF-1 is a member of the NKx2 family of... more
Product information "Anti-NKX2.1 / TTF-1, clone HBNK2-2R"
1 mg/ml in 1X PBS, BSA free, sodium azide free. NKX2.1/TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-NKX2.1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. NKX2.1 reactivity is also seen in thyroid malignancies. Protein function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. [The UniProt Consortium]
Keywords: Anti-T/EBP, Anti-TTF-1, Anti-NKX2A, Anti-Homeobox protein Nkx-2.1, Anti-Thyroid nuclear factor 1, Anti-Thyroid transcription factor 1, Anti-Homeobox protein NK-2 homolog A, Anti-Thyroid-specific enhancer-binding protein, NKX2.1 Antibody / TTF-1
Supplier: NSJ Bioreagents
Supplier-Nr: V3732SAF

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: HBNK2-2R
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant protein was used as the immunogen for the recombinant NKX2.1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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