Anti-TTF-1 Cocktail, clone 8G7G3/1 + NX2.1/690

Anti-TTF-1 Cocktail, clone 8G7G3/1 + NX2.1/690
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2895-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V2895-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 40kDa,... more
Product information "Anti-TTF-1 Cocktail, clone 8G7G3/1 + NX2.1/690"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies. Protein function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. [The UniProt Consortium]
Keywords: Anti-TTF-1, Anti-T/EBP, Anti-NKX2A, Anti-Thyroid nuclear factor 1, Anti-Homeobox protein Nkx-2.1, Anti-Thyroid transcription factor 1, Anti-Homeobox protein NK-2 homolog A, Anti-Thyroid-specific enhancer-binding protein, TTF-1 Antibody Cocktail
Supplier: NSJ Bioreagents
Supplier-Nr: V2895-20UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Mixed
Clone: 8G7G3/1+NX2.1/690
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: Full length rat TTF-1 recombinant protein (8G7G3/1), Recombinant TTF-1 protein (NX2.1/690)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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