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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30769 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The Tachykinin receptor 1 (TACR1), also... more
Product information "Anti-NK1R Neurokinin 1 Receptor"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The Tachykinin receptor 1 (TACR1), also known as Neurokinin 1 receptor (NK1R) or Substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. The protein consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane(TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins. The NK1R can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to NK1R has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. NK1R antagonists have also been studied in migraine, emesis and psychiatric disorders. Protein function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. [The UniProt Consortium]
Keywords: | Anti-SPR, Anti-NK1R, Anti-NK-1R, Anti-TACR1, Anti-NK-1 receptor, Anti-Substance-P receptor, Anti-Tachykinin receptor 1, NK1R Antibody Neurokinin 1 Receptor |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30769 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | An amino acid sequence from the middle region of human Neurokinin 1 Receptor (DSSDRYHEQVSAKRK) was used as the immunogen for this NK1R antibody (100% homologous in human, mouse and rat). |
Format: | Purified |
Database Information
KEGG ID : | K04222 | Matching products |
UniProt ID : | P25103 | Matching products |
Gene ID | GeneID 6869 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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