106 products were found matching "K04222"!

An internal standard for the quantification of substance P by GC- or LC-MS. SMILES:...

An internal standard for the quantification of hemokinin 1 by GC- or LC-MS. SMILES:...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. NKR1 antibody detects Neurokinin 1 receptor, a G protein-coupled receptor (GPCR) encoded by the TACR1 gene on chromosome 2p12 that mediates the biological effects of the neuropeptide Substance P. This...

Tachykinins are peptides sharing the common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH2. This neuropeptide family is composed of substance P, neurokinin A, and neurokinin B, which are widely distributed in mammalian central and peripheral nervous systems. It plays a role as both a neurotransmitter and a...

A peptide antagonist of the NK1 receptor (Ki = 1.51 nM), selective for the NK1 receptor over the NK3 receptor (Ki = 457 nM), increases the percentage of cell clusters displaying neurite outgrowth and inhibits toxicity induced by amyloid-beta peptides in NB41A3 cells at 2.5 µM, induces contraction in isolated and...

A peptide antagonist of NK1 and NK2 receptors (Kis = 2.4 and 19.05 nM, respectively), induces histamine release from isolated rat mast cells (EC50 = 3.2 µM), inhibits bombesin-induced contractions in isolated and perfused guinea pig taenia coli at 10 µM, decreases ear swelling in a mouse model of...

A peptide antagonist of the NK1 receptor (Ki = 177.83 nM), selective for NK1 receptors over NK1 and NK3 receptors (Kis = 5,000 and >10,000 nM, respectively), induces histamine release from isolated rat mast cells (EC50 = 2.5 µM), inhibits neurokinin B-induced contractions in isolated and perfused guinea pig taenia...

An NK1 and NK2 receptor peptide agonist, binds to membrane preparations of rat submandibular gland and hamster urinary bladder (Kis = 0.9 and 2 nM, respectively), tissues that endogenously express high levels of NK1 and NK2 receptors, respectively, increases intracellular levels of IP3 in KNRK rat kidney cells...

A tachykinin neuropeptide and NK1 receptor agonist, binds to NK1 receptors (Ki = 0.175 nM) and induces contractions in isolated rat urinary bladder (EC50 = 100 nM), knockdown of Tac4 inhibits neurogenic inflammation-induced mechanical and thermal hypersensitivity and visceral nocifensive behavior in mice, Tac4-/-...

A derivative of C14TKL-1. Formulation: A solid. InChI:...

Lanepitant is a neurokinin-1 (NK1) receptor antagonist (Ki = 0. nM). It inhibits Ac-[Arg6,Sar9,Met(O2)11]-substance P6-11-induced increases in tail biting and scratching in mice when administered at doses of 1, 5, or 10 mg/kg. Lanepitant (10 mg/kg) inhibits late-phase formalin-induced increases in paw licking in...

Befetupitant is a neurokinin-1 (NK1) receptor antagonist (Ki = 1 nM). It inhibits GR73632-induced foot tapping in gerbils (ID50 = 0. mg/kg). Topical administration of befetupitant (0. or 1. mg/ml for four days) decreases hemangiogenesis and lymphangiogenesis but induces corneal opacity, stromal leukocyte...