Anti-Nicastrin

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A304-464A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A304-464A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that... more

Close menu

Product information "Anti-Nicastrin"

Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma- secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. [The UniProt Consortium]

Keywords:	Anti-NCSTN, Anti-KIAA0253, Anti-Nicastrin
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-464A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: dog, guinea pig_10141, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, naked mole rat, crab-eating macaque, european domestic ferret, northern white-cheeked gibbon, chinese tree shrew)
Immunogen:	synthetic peptide. The epitope recognized by A304-464A-T maps to a region between residue 659 to 709 of human Nicastrin using the numbering given in entry NP_056146.1 (GeneID 23385).
Format:	Antigen Affinity Purified