Anti-NEDD4

Anti-NEDD4
Promotion:

Bethyl is giving away a free permanent marker for every Bethyl purchase until supplies last!

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-253A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A303-253A 100 µl (100 µg) -

3 - 9 business days

430.00€
 
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2... more
Product information "Anti-NEDD4"
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). [The UniProt Consortium]
Keywords: Anti-PIG53, Anti-NEDD4, Anti-NEDD-4, Anti-KIAA0093, Anti-E3 ubiquitin-protein ligase NEDD4, Anti-HECT-type E3 ubiquitin transferase NEDD4, Anti-Cell proliferation-inducing gene 53 protein
Supplier: Bethyl Laboratories
Supplier-Nr: A303-253A-T

Properties

Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Dog, Horse, Rabbit, Panda, Orangutan, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Small-eared Galago, Thirteen-lined Ground Squirrel, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-253A-T maps to a region between residue 725 and 775 of human Neural Precursor Cell Expressed, Developmentally Down-regulated 4 using the numbering given in entry AAI36606.1 (GeneID 4734).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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