Anti-Mouse CD71, PE/Cyanine5 conjugated, clone R17 217.1.3/TIB-219

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-F1093G.200 200 tests -

7 - 16 business days*

273.00€
 
CD71 is a 95 kD type II heterodimeric transmembrane glycoprotein that is also known as T9 and... more
Product information "Anti-Mouse CD71, PE/Cyanine5 conjugated, clone R17 217.1.3/TIB-219"
CD71 is a 95 kD type II heterodimeric transmembrane glycoprotein that is also known as T9 and transferrin receptor. CD71 is expressed on proliferating cells, reticulocytes, and erythroid precursors. Its expression is very low on resting leukocytes. CD71 plays a role in the control of cellular proliferation by facilitating the uptake of iron via ferrotransferrin binding and the recycling of apotransferrin to the cell surface. Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. [The UniProt Consortium]
Keywords: Anti-TR, Anti-TfR, Anti-TfR1, Anti-CD71, Anti-Tfrc, Anti-Trfr, Anti-Transferrin receptor protein 1, PE/Cyanine5 Anti-Mouse CD71 Antibody[R17 217.1.3/TIB-219]
Supplier: Elabscience
Supplier-Nr: E-AB-F1093G

Properties

Application: FC, FC (membrane)
Antibody Type: Monoclonal
Clone: R17 217.1.3/TIB-219
Conjugate: PE/Cy5
Host: Rat
Species reactivity: mouse

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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