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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A302-658A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A302-658A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP... more
Product information "Anti-MKK4"
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. [The UniProt Consortium]
Keywords: | Anti-JNKK, Anti-SEK1, Anti-MEK 4, Anti-JNKK1, Anti-MAP2K4, Anti-SAPKK1, Anti-SAPKK-1, Anti-MAPKK 4, EC=2.7.12.2, Anti-SAPK kinase 1, Anti-SAPK/ERK kinase 1, Anti-MAPK/ERK kinase 4, Anti-MAP kinase kinase 4, Anti-JNK-activating kinase 1 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A302-658A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: rat, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, pig, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A302-658A-T maps to a region between residue 349 and 399 of human dual specificity mitogen-activated protein kinase kinase 4 using the numbering given in entry NP_003001.1 (GeneID 6416). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K04430 | Matching products |
UniProt ID : | P45985 | Matching products |
Gene ID | GeneID 6416 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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