Anti-MKK4

Anti-MKK4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-658A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-658A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-658A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP... more
Product information "Anti-MKK4"
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. [The UniProt Consortium]
Keywords: Anti-JNKK, Anti-SEK1, Anti-MEK 4, Anti-JNKK1, Anti-MAP2K4, Anti-SAPKK1, Anti-SAPKK-1, Anti-MAPKK 4, EC=2.7.12.2, Anti-SAPK kinase 1, Anti-SAPK/ERK kinase 1, Anti-MAPK/ERK kinase 4, Anti-MAP kinase kinase 4, Anti-JNK-activating kinase 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-658A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig_10141, Pig, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-658A-T maps to a region between residue 349 and 399 of human dual specificity mitogen-activated protein kinase kinase 4 using the numbering given in entry NP_003001.1 (GeneID 6416).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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