Anti-MKK3, CT (Dual Specificity Mitogen-activated Protein Kinase Kinase 3, MAP Kinase Kinase 3, MAPK

Anti-MKK3, CT (Dual Specificity Mitogen-activated Protein Kinase Kinase 3, MAP Kinase Kinase 3, MAPK
Item number Size Datasheet Manual SDS Delivery time Quantity Price
M2363-10N.100 100 µl - -

1 - 19 business days

496.00€
 
MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP... more
Product information "Anti-MKK3, CT (Dual Specificity Mitogen-activated Protein Kinase Kinase 3, MAP Kinase Kinase 3, MAPK"
MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site Thr-Gly-Tyr but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines (4,5). Activation of MKK3 and MKK6 occurs through phosphorylation of serine and threonine residues at sites Ser189 and Thr193 for MKK3 (2) and Ser207 and Thr211 for MKK6 (4,5). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=2.7.12.2, Anti-SAPKK2, Anti-SAPKK-2, Anti-SAPK kinase 2, Anti-MAPK/ERK kinase 3, Anti-MAP kinase kinase 3, Anti-Stress-activated protein kinase kinase 2, Anti-Dual specificity mitogen-activated protein kinase kinase 3
Supplier: United States Biological
Supplier-Nr: M2363-10N

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Synthetic peptide corresponding to residues near the C-terminus of human MKK3.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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