Anti-MAGE-1, clone MA454

Anti-MAGE-1, clone MA454
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3136SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a protein of 42-46kDa, identified... more
Product information "Anti-MAGE-1, clone MA454"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a protein of 42-46kDa, identified as MAGE-1. This mAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy. Protein function: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. [The UniProt Consortium]
Keywords: Anti-CT1.1, Anti-MAGE1, Anti-MAGEA1, Anti-Antigen MZ2-E, Anti-MAGE-1 antigen, Anti-Cancer/testis antigen 1.1, Anti-Melanoma-associated antigen 1, MAGE-1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3136SAF-100UG

Properties

Application: WB, FC, IF, IHC
Antibody Type: Monoclonal
Clone: MA454
Conjugate: No
Host: Mouse
Reactivity: Human, Rat, Dog
Immunogen: Full length human protein was used as the immunogen for this MAGE-1 antibody.
Format: Purified

Database Information

UniProt ID : P43355 | Find alternatives
Gene ID GeneID 4100 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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