Anti-LRRC8A

Anti-LRRC8A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-175A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-175A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-175A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Essential component of the volume-regulated anion channel (VRAC, also named... more
Product information "Anti-LRRC8A"
Protein function: Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E), channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development. [The UniProt Consortium]
Keywords: Anti-LRRC8A, Anti-KIAA1437, Anti-Swelling protein 1, Anti-Leucine-rich repeat-containing protein 8A, Anti-Volume-regulated anion channel subunit LRRC8A
Supplier: Bethyl Laboratories
Supplier-Nr: A304-175A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat)
Immunogen: synthetic peptide. The epitope recognized by A304-175A-T maps to a region between residue 760 to 810 of human Leucine Rich Repeat Containing 8 Family, Member A using the numbering given in entry NP_001120716.1 (GeneID 56262).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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