Anti-LPP

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Lim Domain-Containing Preferred Translocation Partner in Lipoma is a protein that in humans is encoded by the LPP gene. Petit et al.(1996) commented that the LPP-encoded protein should be classified as a novel member of the group 3 proteins of the LIM protein gene family. By partial cDNA cloning, Petit et al.(1996) established features of the genetic organization of LPP. The gene was found to span a genomic region of over 400 kb. By FISH and Southern blot analyses, Daheron et al.(2001) identified a rearrangement in the mixed lineage leukemia gene due to a novel t(3,11)(q28,q23) translocation in a patient who developed acute myeloid leukemia of the M5 type 3 years after treatment for a follicular lymphoma. Protein function: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. [The UniProt Consortium]