Anti-LIN28B

Anti-LIN28B
Anti-LIN28B
Anti-LIN28B
     
%
Discount Promotion
Promotion:

Save 30% on all primary antibodies by Arigo Biolaboratories!

*1
*1 Offer expires 16/12/2024
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG41857.100 100 µl - -

6 - 14 business days*

30 %
624.00€
436.80€
 
Protein function: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly... more
Product information "Anti-LIN28B"
Protein function: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11- independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression. When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. [The UniProt Consortium]
Keywords: Anti-CSDD2, Anti-LIN28B, Anti-Lin-28B, Anti-Protein lin-28 homolog B
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG41857

Properties

Application: FC, IHC (paraffin), WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: KLH-conjugated synthetic peptide between aa. 95-128 of Human LIN28B
MW: 27 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-LIN28B"
Write a review
or to review a product.
Anti-LIN28B Anti-LIN28B
From 164.00€ *
Anti-LIN28B Anti-LIN28B
From 164.00€ *
Anti-LIN28B Anti-LIN28B
574.00€ *
-30 %
Discount Promotion
Anti-LIN28B Anti-LIN28B
624.00€ * 436.80€ *
Viewed