Anti-KLK6 / Kallikrein 6

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F54850-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F54850-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Kallikreins are a subgroup of serine proteases having... more
Product information "Anti-KLK6 / Kallikrein 6"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Protein function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. [The UniProt Consortium]
Keywords: Anti-SP59, Anti-KLK6, Anti-Zyme, Anti-PRSS18, Anti-Neurosin, Anti-Protease M, EC=3.4.21.-, Anti-Kallikrein-6, Anti-Serine protease 9, Anti-Serine protease 18, KLK6 Antibody / Kallikrein 6
Supplier: NSJ Bioreagents
Supplier-Nr: F54850

Properties

Application: WB, FC, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 1-30 from the human protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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