Anti-KEAP1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
NSJ-F40464-0.08ML	80 µl		-	-	3 - 10 business days*		361.00€
NSJ-F40464-0.4ML	400 µl		-	-	3 - 10 business days*		772.00€

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In 1X PBS, pH 7.4, with 0.09% sodium azide. KEAP1 acts as a substrate adapter protein for the E3... more

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Product information "Anti-KEAP1"

In 1X PBS, pH 7.4, with 0.09% sodium azide. KEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome [UniProt] Protein function: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. [The UniProt Consortium]

Keywords:	Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like ECH-associated protein 1, KEAP1 Antibody
Supplier:	NSJ Bioreagents
Supplier-Nr:	F40464

Properties

Application:	WB, IHC, ELISA
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	A portion of amino acids 422-449 from the human protein was used as the immunogen for this KEAP1 antibody.
Format:	Purified