Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00370-T 10 µl (5+ slides) -

3 - 9 business days*

IHC-00370 100 µl (50+ slides) -

3 - 9 business days*

Protein function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a... more
Product information "Anti-JARID1B (IHC)"
Protein function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. [The UniProt Consortium]
Keywords: Anti-CT31, Anti-PLU-1, Anti-KDM5B, Anti-JARID1B, Anti-RBP2-H1, EC=1.14.11.-, Anti-Cancer/testis antigen 31, Anti-Histone demethylase JARID1B, Anti-Lysine-specific demethylase 5B, Anti-Jumonji/ARID domain-containing protein 1B
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00370


Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Dog, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Small-eared Galago, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00370 maps to a region between residue 1494 and 1544 of human Jumonji, AT rich interactive domain 1B using the numbering given in entry NP_006609.3 (GeneID 10765).
Format: Antigen Affinity Purified

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Our products are for laboratory research use only: Not for administration to humans!
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