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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10005518-1 | 1 each | - |
6 - 10 business days* |
422.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The IP Receptor is a class A rhodopsin-like G protein-coupled receptor that mediates the actions... more
Product information "Anti-IP Receptor (human)"
The IP Receptor is a class A rhodopsin-like G protein-coupled receptor that mediates the actions of prostaglandin I2 (PGI2). The C-terminal intracellular tail of the IP receptor undergoes isoprenylation and palmitoylation that results in anchoring of the tail to the plasma membrane. The IP receptor is expressed in platelets and vascular smooth muscle cells and in the aorta, lungs, heart, and kidneys. It signals through G proteins in a cell type- and expression-dependent manner and is involved in cardiovascular, inflammatory, and immune functions, as well as the pain response. An arginine-to-cysteine mutation at position 212 in the IP receptor inhibits its ability to activate adenylyl cyclase, which leads to increased platelet aggregation ex vivo and increases disease severity and the incidence of cardiovascular events in patients with a high risk of cardiovascular disease. The human IP receptor is N-terminally truncated by 28 amino acids compared with the murine receptor. Cayman's IP Receptor (human) Polyclonal Antibody can be used for Western blot (WB). The antibody recognizes the IP receptor at approximately 42 kDa from human and mouse samples.Synonyms: PGI2 Receptor, Prostacyclin Receptor, Prostaglandin I2 Receptor. Immunogen: Synthetic peptide from the N-terminal region of human IP receptor. MW: ~42 kDa. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (+) IP Receptor. UniProt Accession #: P43119. Origin: Animal/Rabbit.
Keywords: | Anti-PTGIR, Anti-PRIPR, Anti-PGI receptor, Anti-PGI receptor, Anti-PGI2 receptor, Anti-PGI2 receptor, Anti-Prostacyclin receptor, Anti-Prostacyclin receptor, Anti-Prostanoid IP receptor, Anti-Prostanoid IP receptor, Anti-Prostaglandin I2 receptor, Anti-Pr |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10005518 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, murine, rat (Expected: bovine, canine) |
Immunogen: | Synthetic peptide from the N-terminal region of human IP receptor |
Format: | Solid |
Database Information
KEGG ID : | K04263 | Matching products |
UniProt ID : | P43119 | Matching products |
Gene ID | GeneID 5739 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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