38 products were found matching "K04263"!

An IP receptor antagonist (Ki = 20 nM in isolated human platelets), selective for the IP receptor over a panel of 50 receptors at 10 µM but does bind to EP3, EP4, and TP receptors and the adenosine A3 receptor (Kis = 4,169, 1,820, 8,128, and 4,786 nM, respectively), inhibits carbaprostacyclin-induced cAMP...

Immunogen: Purified membrane fractions from OCI-LY7 cells  Host: Mouse  Species Reactivity: (+) Human  Cross Reactivity: (+) TfR1  Applications: IC, FC. SMILES: . InChi Code: . InChi Key:

Recombinant CHO-K1 cells stably overexpress human prostaglandin I2 receptor (PTGIR) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

MRE-269-d6 is intended for use as an internal standard for the quantification of MRE-269 (Cay-10010412) by GC- or LC-MS. MRE-269 is an IP receptor agonist and an active metabolite of NS 304 (Cay-10010411). It is formed from NS 304 primarily via carboxylesterase 1 (CES1) in human liver microsomes and via CES2 in...

NS 304-d6 is intended for use as an internal standard for the quantification of NS 304 (Cay-10010411) by GC- or LC-MS. NS 304 is an IP receptor agonist and a prodrug form of MRE-269 (Cay-10010412). It binds to the IP receptor (Ki = 260 nM for the human receptor) and induces cAMP accumulation in CHO cells expressing...

Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin (Cay-18220) that is used clinically for the treatment of PPH under the trade name Remodulin(TM). The structural...

The IP Receptor is a class A rhodopsin-like G protein-coupled receptor that mediates the actions of prostaglandin I2 (PGI2). The C-terminal intracellular tail of the IP receptor undergoes isoprenylation and palmitoylation that results in anchoring of the tail to the plasma membrane. The IP receptor is expressed in...

The IP Receptor is a class A rhodopsin-like G protein-coupled receptor that mediates the actions of prostaglandin I2 (PGI2). The C-terminal intracellular tail of the IP receptor undergoes isoprenylation and palmitoylation that results in anchoring of the tail to the plasma membrane. The IP receptor is expressed in...

Protein function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. [The UniProt Consortium]

AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM). It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PTGIR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PTGIR. Next,...

Iloprost-d4 is intended for use as an internal standard for the quantification of iloprost (Cay-18215) by GC- or LC-MS. Iloprost is an agonist of the IP receptor and the prostaglandin E2 (PGE2) receptor subtype EP1 and a derivative of PGI2. It selectively binds to IP and EP1 receptors (Ki = 11 nM for both) over EP2,...