Anti-IL10, clone 530CT10.5.7

Anti-IL10, clone 530CT10.5.7
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F53677-0.1ML 100 µl - -

3 - 10 business days*

702.00€
 
In ascites with 0.09% sodium azide. IL10 inhibits the synthesis of a number of cytokines,... more
Product information "Anti-IL10, clone 530CT10.5.7"
In ascites with 0.09% sodium azide. IL10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. [UniProt] Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines including granulocyte-macrophage colony- stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G- CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co- stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. [The UniProt Consortium]
Keywords: Anti-IL10, Anti-CSIF, Anti-IL-10, Anti-Interleukin-10, Anti-Cytokine synthesis inhibitory factor, IL10 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F53677

Properties

Application: WB, ELISA
Antibody Type: Monoclonal
Clone: 530CT10.5.7
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Portion of amino acids 27-53 from the human protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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