Anti-IKK-beta

Anti-IKK-beta
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-827A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-827A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-827A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway... more
Product information "Anti-IKK-beta"
Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF- dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. [The UniProt Consortium]
Keywords: Anti-IKK2, Anti-IKKB, Anti-IKK-B, Anti-IKBKB, Anti-IkBKB, Anti-NFKBIKB, Anti-IKK-beta, EC=2.7.11.10, Anti-I-kappa-B kinase 2, Anti-I-kappa-B-kinase beta, Anti-Nuclear factor NF-kappa-B inhibitor kinase beta
Supplier: Bethyl Laboratories
Supplier-Nr: A301-827A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque)
Immunogen: synthetic peptide. The epitope recognized by A301-827A-T maps to a region between residue 706 and 756 of human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta using the numbering given in entry NP_001547.1 (GeneID 3551).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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