Anti-IDH1 / Isocitrate Dehydrogenase, clone IDH1/1152

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2609SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. It recognizes a 45kDa protein, which is... more
Product information "Anti-IDH1 / Isocitrate Dehydrogenase, clone IDH1/1152"
1 mg/ml in 1X PBS, BSA free, sodium azide free. It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming a-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of a-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway. Protein function: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. [The UniProt Consortium]
Keywords: Anti-IDH, Anti-IDPc, Anti-IDH1, Anti-PICD, Anti-NADP(+)-specific ICDH, Anti-Oxalosuccinate decarboxylase, Anti-Cytosolic NADP-isocitrate dehydrogenase, Anti-Isocitrate dehydrogenase [NADP] cytoplasmic, IDH1 Antibody / Isocitrate Dehydrogenase
Supplier: NSJ Bioreagents
Supplier-Nr: V2609SAF

Properties

Application: IHC (paraffin), IF
Antibody Type: Monoclonal
Clone: IDH1/1152
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A recombinant fragment (119 amino acid residues around aa 280-420) from the human protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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