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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I0650-01S.100 | 100 tests | - | - |
3 - 19 business days* |
914.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Inducible co-stimulator also called AILIM and CRP-1 (CD28-related protein-1), is a member of the... more
Product information "Anti-ICOS (CD278, Inducible T-cell Costimulator, Activation-inducible Lymphocyte Immunomediatory Mol"
Inducible co-stimulator also called AILIM and CRP-1 (CD28-related protein-1), is a member of the CD28 family of immune co-stimulatory receptors. Other family members are CD28, CTLA-4, and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199aa with a putative 20aa signal sequence, a 121aa extracellular domain, a 23aa transmembrane region, and a 35aa cytoplasmic domain. ICOS shares ~39% aa similarity with CD28 and CTLA-4. Human and mouse ICOS share ~72% aa identity. ICOS is expressed on most CD45RO+ cells. ICOS expression is up-regulated within ~24-48h of activation on T helper (Th) primed cells. B7-H2, a member of the B7 family of co-stimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ ICOS interaction appears to play roles in T cell-dependent B cell activation and Th differentiation. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Excitation: 620-650nm , Emission: 660-670nm, Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
Supplier: | United States Biological |
Supplier-Nr: | I0650-01S |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 12K105 |
Conjugate: | APC |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to human ICOS expressed in NSO cell line. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06713 | Matching products |
UniProt ID : | Q9Y6W8 | Matching products |
Gene ID : | GeneID 29851 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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