Anti-HPV-16 L1, clone SPM405

Anti-HPV-16 L1, clone SPM405
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3063-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3063-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Reacts with a protein of 57kDa,... more
Product information "Anti-HPV-16 L1, clone SPM405"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Reacts with a protein of 57kDa, identified as the L1 protein of human papilloma virus type 16 (HPV-16). It is the major capsid protein of HPV-16. Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies. The antibody reacts very strongly with formalin-fixed, paraffin-embedded tissues containing HPV-16 or -33, very weak reactions were occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. It cross-reacts with HPV37. Protein function: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. [The UniProt Consortium]
Keywords: Anti-L1, Anti-Major capsid protein L1, HPV-16 L1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3063-20UG

Properties

Application: IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM405
Conjugate: No
Host: Mouse
Reactivity: Type 16 Of Human Papilloma Virus (hpv-16)
Immunogen: Recombinant major capsid protein L1 from human papilloma virus type 16
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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